КЛИК Роберт Л. (US),КАЛЛИ Эдвард Х. (US),ДРАМХЕЛЛЕР Пол Д. (US),ХОЛЛАНД Тереза А. (US)
申请号：
RU2015113410
公开号：
RU2015113410A
申请日:
2013.09.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method of obtaining a water-in-solvent emulsion, comprising the following steps: a. dissolving the tetrafluoroethylene copolymer in a water-miscible organic solvent b. providing the aqueous phase c. dissolving an agent containing one of a water soluble agent and a hydrophobic agent； and d. combining a tetrafluoroethylene copolymer with a dissolved agent so that the emulsion is kinetically stable. 2. The method of claim 1, wherein said agent is a therapeutic agent. A method according to claim 1, characterized in that said agent is an inclusion complex containing a hydrophobic agent and a hydrophilic complexing agent. A method according to claim 1, characterized in that said agent is a water-soluble agent that is dissolved in the aqueous phase. A method of coating a substrate containing a water-in-solvent emulsion, comprising the steps of: a. providing a water-in-solvent emulsion containing a tetrafluoroethylene copolymer, a solvent phase containing a water-miscible organic solvent, an agent containing one of a water-soluble agent and a hydrophobic agent, an aqueous phase where said emulsion is kinetically stable； b. applying a water-in-solvent emulsion to a substrate； c. solvent and water removal. 6. The method of claim 5, wherein said agent is an inclusion complex comprising a hydrophobic agent and a hydrophilic complexing agent. A method according to claim 5, characterized in that said aqueous phase is less than about 500 nm according to Raman spectroscopy. The method of claim 5, wherein said copolymer1. Способ получения эмульсии вода-в-растворителе, включающий следующие стадии:a. растворение сополимера тетрафторэтилена в смешиваемом с водой органическом растворителе；b. обеспечение водной фазы；c. растворение агента, содержащего одно из водорастворимого агента и гидрофобного агента； иd. объединение сополимера тетрафторэтилена с растворенным агентом таким образом, чтобы эмульсия являлась кинетически устойчивой.2. Способ по п. 1, отличающийся тем, что указанный а
