ALEKSZANDER Rikki Piter (GB),АЛЕКСЗАНДЕР Рикки Питер (GB),BRAUN Dzhulien Alister (GB),БРАУН Джулиен Алистэр (GB),DELINI Mikhael (BE),ДЕЛИНЬИ Михаэль (BE),KHER Yag Paul (BE),ХЕР Яг Паул (BE),DZHEKSON V
申请号：
RU2016127230
公开号：
RU0002700004C9
申请日:
2014.12.08
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, specifically to a compound of formula (I)or a pharmaceutically acceptable salt thereof, in which n denotes an integer equal to 1 or 2； Y denotes aryl, thiazole, pyrimidine, pyrazine, where any of these groups can optionally contain one or two substitutes selected from a difluoromethoxy group, trifluoromethoxy group, methyl, trifluoromethyl, methylsulphonyl, halogen, methoxy group, cyano； X and Z are independently denoted by a heteroatom selected from N or O； or unsubstituted linear C1-C4-alkylene chain； R1 denotes aryl, C3-C7-heterocycloalkyl selected from piperidine, piperazine, azetidine or pyrrolidine, heteroaryl selected from pyridine, pyrimidine or pyrazole, heteroaryl (C1-C6) alkyl, where heteroaryl is selected from pyridine, pyrimidine or pyrazole, heteroaryl (C3-C7) heterocycloalkyl-, where heteroaryl is selected from pyrimidine and pyridine, and heterocycloalkyl is selected from morpholine, piperazine, piperidine, tetrahydrofuran, pyrrolidine, dioxydotetetrahydrothiophene, (C3-C7)cycloalkyl-heteroaryl-, where heteroaryl is selected from pyrazole and pyridine, heteroaryl-aryl-, selected from dihydroisoindolyl and triazolyl, where any of these groups may optionally contain one or two substitutes selected from C1-C6-alkyl, methoxy groups, methoxy(C1-C6)alkyl, methylsulphonyl, phenylsulphonyl, acetamide, methylcarboxylate, tert-butyl carboxylate, cyano, hydroxyalkyl, ethoxycarbonyl, carboxy groups, methylpropane nitrile, propanol, halogen (C1-C6)alkyl； R2 denotes hydrogen, halogen, trifluoromethyl or cyano； or C1-C6-alkyl, optionally substituted C2-C6-alkoxycarbonyl； R3 and R4 independently denote hydrogen； R5a and R5b independently denote hydrogen, hydroxy group； or R5a and R5b together with carbon atom to which they are attached, denote carbonyl； and R6 independently denotes hydrogen, hydroxy group. Invention also relates to a pharmaceutical composition based on formula (I), use of the compou
