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N(ARYLALKYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
专利权人:
SANOFI-AVENTIS
发明人:
DUBOIS LAURENT,EVANNO, YANNICK,MALANDA, ANDRE
申请号:
CA2615676
公开号:
CA2615676C
申请日:
2006.07.19
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention relates to compounds of formula (I): wherein n is 0, 1, 2 or 3; the pyrrolopyridine ring is a pyrrolo [3,2-b] pyridine group, a pyrrolo [3,2-c] pyridine group, a pyrrolo [2,3-c] pyridine group or a pyrrolo [2,3-b] group pyridine; the pyrrolopyridine ring being optionally substituted, in carbon position 4, 5, 6 and / or 7, with one or more substituents X, which are identical or different from one another; Z1, Z2, Z3, Z4 and Z5 represent, independently of one another, a hydrogen or halogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl- C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, cyano, C (O) NR1R2, nitro, NR1R2, C1-C6-thioalkyl, -S (O) -C1- C6-alkyl, -S (O) 2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene or aryl, aryl and raryl-C1-C6-alkylene being optionally substituted; W represents a fused bicyclic group of the formula: (see formula II) attached to the nitrogen atom at the 1, 2, 3 or 4 positions; A represents an optionally substituted 5- to 7-membered heterocycle comprising from one to three heteroatoms selected from O, S or N; the basic state or acid addition salt, as well as the hydrate or solvate state. The invention also relates to a process for the preparation of said compounds of formula (I) and their therapeutic use. (see formula I)L'invention concerne des composé de formule (l): dans laquelle n est égal à 0, 1, 2 ou 3; le noyau pyrrolopyridine est un groupe pyrrolo[3,2-b]pyridine, un groupe pyrrolo[3,2-c]pyridine, un groupe pyrrolo[2,3-c]pyridine ou un groupe pyrrolo[2,3-b] pyridine; le noyau pyrrolopyridine étant éventuellement substitué, en position carbonée 4, 5, 6 et/ou 7, par un ou plusieurs substituents X, identiques ou différents l'un de l'autre; Z1, Z2, Z3, Z4 et Z5 représentent, indépendamment l'un de l'autre, un atome d'hydrogène ou d'halogène ou un groupe C1-C6-alkyle, C3-C7-cycloalkyle, C3-C7-cycloalkyle-C1-C3-alkylène, C1-C6-fluoroalkyle, C1-C6-alcoxyle, C1-C6-fluoroalcoxyle,
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