Kalish, Vincent Jacob,Brookfield, Frederick Arthur,Courtney, Stephen Martin,Frost, Lisa Marie,Toscano, John,Reardon, John
申请号：
NZ74877114
公开号：
NZ748771A
申请日:
2014.01.17
申请国别(地区):
NZ
年份:
2019
代理人:
摘要：
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration, and include pharmaceutical compositions that comprise a N-hydroxysulfonamide type nitroxyl donor and an aqueous buffer, wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (2) and wherein the composition has a pH of from about 5 to about 6.5.
