A surgical access device (100,200,300,400) is disclosed herein. The surgical access device (100,200,300,400) includes a housing (110,210,310,410) adapted for insertion into an incision in tissue ("T" ) and at least one inflatable portion (130,230,240,250,330,430) disposed on the housing (110,210,310,410). The housing (110,210,310,410) defines a proximal end (112,212,312,412) and a distal end (114,214,314,414) and has a lumen (116,216,316,416) extending therethrough for the reception of a surgical access portal ("S1","S2"). The at least one inflatable portion (130,230,240,250,330,430) has a deflated state and an inflated state and the housing (110,210,310,410) is insertable into the incision in tissue ("T") when the at least one inflatable portion (130,230,240,250,330,430) is in the deflated state. The housing (110,210,310,410) is adapted to form a substantially fluid tight seal with the incision in tissue ("T") and with a surgical access portal ("S1","S2") inserted therethrough when the at least one inflatable portion (130,230,240,250,330,430) is in the inflated state.