REISFELD RALPH A.,XIANG RONG,LUO YUNPING,LIAO DEBBIE,LIU ZE,CHEN TINGMEI,CHEN SI,LU DAN
申请号：
NZ60874811
公开号：
NZ608748A
申请日:
2011.09.02
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Provided is a legumain-targeting lipid comprising a lipid bound to a legumain binding moiety wherein the legumain binding moiety comprises an aza-Asn peptide-type legumain inhibitor having a reactive portion of formula (I). Further provided is a legumain-targeting nanoparticle composition comprising lipid nanoparticles comprising the aforementioned legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials. An anti-cancer agent can be encapsulated in the nanoparticles. The lipid is designed to target anti-cancer agents to tumours which overexpress legumain.
