REISFELD, RALPH A.,XIANG, RONG,LUO, YUNPING,LIAO, DEBBIE,LIU, ZE,CHEN, TINGMEI,CHEN, SI,LU, DAN
申请号：
CA2809617
公开号：
CA2809617A1
申请日:
2011.09.02
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component (c) an amino-substituted lipid component (d) a neutral lipid component and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.
