Ralph A. Reisfeld,Rong Xiang,Yunping Luo,Debbie Liao,Ze Liu,Tingmei Chen,Si Chen,Dan Lu
申请号：
US13224399
公开号：
US09616137B2
申请日:
2011.09.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component (c) an amino-substituted lipid component (d) a neutral lipid component and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.
