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NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY
专利权人:
THE SCRIPPS RESEARCH INSTITUTE
发明人:
REISFELD, RALPH A.,XIANG, RONG,LUO, YUNPING,LIAO, DEBBIE,LIU, ZE,CHEN, TINGMEI,CHEN, SI,LU, DAN
申请号:
SG2013015797
公开号:
SG188375A1
申请日:
2011.09.02
申请国别(地区):
SG
年份:
2013
代理人:
摘要:
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component (c) an amino-substituted lipid component (d) a neutral lipid component and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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