REISFELD RALPH A,XIANG RONG,LUO YUNPING,LIAO DEBBIE,LIU ZE,CHEN TINGMEI,CHEN SI,LU DAN
申请号：
IN2412/CHENP/2013
公开号：
IN2013CN02412A
申请日:
2013.03.27
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention provides an aqueous tumor targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti cancer chemotherapeutic agent which can be added to a pre formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain targeting lipid admixed with one or more other micelle or vesicle forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor targeting liposome nanoparticle composition comprises (a) a legumain targeting lipid component (b) a zwitterionic lipid component (c) an amino substituted lipid component (d) a neutral lipid component and (e) polyethylene glycol conjugated lipid component. The legumain targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain binding moiety.
