CHARLOTTE FIELDHOUSE,ANGELA GLEN,STEPHANIE MAINE,TATSUHIKO FUJIMOTO,JOHN STEPHEN ROBINSON
申请号：
ARP150100481
公开号：
AR099495A1
申请日:
2015.02.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Claim 1: a formula compound (1) characterized in that R1 represents an alien group composed of 5 or 6 members, which can be optionally replaced by at least one selected substitute of halogen, cyanogen, hydroxy, cyclopentaacyloc83323226；1. Apartment c83218331；C₁₋₃ alkoxy,C₁₋₃ alkoxycarbonyl,C₁₋₃ alkoxycarbonylamino,Halogenated tar c83218323；C₁₋₃ haloalkoxy,-No. 83088r83099；c. Ring twelve caratC83321xi-833183323 asphalt1. No. c83217c83183323 Baihe reservoir；sulfonamido, C₁₋₃ alkylsulfonyl,alquilsulfonilamino C y -C (O) NR RL for link, ch832222,O or NR¹²；Rᵃ represents a hydrogen atom or a C₁₋₃ alkyl or C₁₋₃ haloalkyl group；Rᵇ represents a hydrogen atom or a C₁₋₃ alkyl or C₁₋₃ haloalkyl group；X for c832222；CHF or cf83222；R² represents a hydrogen atom or a C₁₋₆ alkyl or C₃₋₆ cycloalkyl group；R³ represents a phenyl group or a 5- or 6-membered heteroaryl group, all optionally substituted by at least one substituted by at least one substituent independently selected from halogen, hydroxyl and C₁₋₃ alkoxy；R83041 and R1 represent a hydrogen atom or c832138323 or c83323126 or r18383041 and R1 Coking Group respectively, When nitrogen atoms are added, they are linked together to form a saturated acyclic ring composed of 4 to 7 Selective members, which is replaced by at least one independent halogen and hydroxyl substitute； R1 square represents one hydrogen atom, a. A methyl group or c833228331-832323 asphalt chain, adding R1, forming a ring of 5 or 6 members； or a pharmaceutically acceptable such salt；Reivindicación 1: Un compuesto de fórmula (1) caracterizado por que R¹ representa un grupo heteroarilo de 5 ó 6 miembros opcionalmente sustituido por al menos un sustituyente seleccionado de halógeno, ciano, hidroxilo, cicloalquilo C₃₋₆, alquilo C₁₋₃, alcoxi C₁₋₃, alcoxicarbonilo C₁₋₃, alcoxicarbonilamino C₁₋₃, haloalquilo C₁₋₃, haloalcoxi C₁₋₃, -NR⁴R⁵, cicloalquilamino C₃₋₆, alquilcarboniloxi C₁₋₃, alquilcarbonilamino C₁₋₃, sulfonamido, alquilsulfonilo C₁₋₃, alquilsulfonilamino C₁
