Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО "ФармТех" (RU)
发明人:
Чилов Гермес Григорьевич (RU),Строганов Олег Валентинович (RU),Стройлов Виктор Сергеевич (RU),Новиков Федор Николаевич (RU),Титов Илья Юрьевич (RU)
申请号：
RU2015110071
公开号：
RU2015110071A
申请日:
2015.03.23
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Use of a compound of formula I: or its enantiomer or a pharmaceutically acceptable salt, solvate or hydrate, wherein a dream Lpredstavlyaet CH (CH) Lpredstavlyaet a C (O) NH or NH Ring A is phenyl, optionally substituted with 1-3 groups R and Rvybiraetsya independently represents halogen, partially or completely halogenated C alkyl, OC-alkyl, ring B represents phenyl or 6-membered heteroaryl ring containing 1-2 N atoms ring B optionally comprises 1-3 substituents R and Rvybiraetsya independently represents LR, LH, halogen, partially or completely halogenated C-alkyl Lpredstavlyaet a covalent bond, O, OSNili C (O) Rvybiraetsya and independently represents a C alkyl, 4-6 membered geteroalitsiklil containing 1-2 N atoms and 0-1 O atoms Rneobyazatelno contains 1-3 substituents R and Rvybiraetsya independently represents halogen, CH, NHR, N (R), or a 5-6 membered geteroalitsiklil containing 0-1 N atoms and 0-1 O atoms Rneobyazatelno contains 1-2 substituents independently selected from C-alkyl Rvybiraetsya and independently represents a C alkyl group for the preparation of a pharmaceutical composition for the treatment and / or prevention of a disease associated with aberrant activity NUAK1 kinazy.2. . Use according to claim 1, wherein: Lpredstavlyaet is CH Lpredstavlyaet a C (O) NH Ring A is phenyl, optionally substituted with 1-3 groups R and Rvybiraetsya independently represents halogen or CF ring B represents phenyl ring B optionally comprises 1-3 substituents R and Rvybiraetsya independently represents LR, LH Lpredstavlyaet a covalent bond, O, OSNili C (O) Rvybiraetsya and independently represents a 4-6 membered geteroalitsiklil containing 1-2 N atoms and 0-1
