MOSS, STEVEN JAMES,GREGORY, MATTHEW ALAN,WILKINSON, BARRIE,MARTIN, CHRISTINE JANET
申请号：
ES11704308
公开号：
ES2541853T3
申请日:
2011.02.09
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound according to formula (I) below, or a pharmaceutically acceptable salt thereof: ** Formula ** in which: R1 and R2 independently represent alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylcycloalkyl, alkylcycloalkenyl, alkenylcycloalkyl, alkenylcycloalkenyl, aryl, heteroaryl, alkylaryl, alkylheteroaryl, alkenylaryl or alkenylheteroaryl, any of these groups may be optionally substituted with monocyclic aryl or monocyclic heteroaryl； or R1 and / or R2 represents hydrogen； and wherein one or more carbon atoms of R1 and / or R2 that are not part of an aryl or heteroaryl group are optionally replaced by a heteroatom selected from O, N and S (O) p in which p represents 0, 1 or 2 and wherein one or more carbon atoms of R1 and / or R2 are optionally replaced by carbonyl； or R1 and R2 are joined to form a saturated or unsaturated heterocyclic ring containing the nitrogen atom shown and in which one or more carbon atoms of said ring are optionally replaced by a heteroatom selected from O, N and S (O) p in which p represents 0, 1 or 2 and in which one or more carbon atoms of said ring are optionally replaced by carbonyl and the heterocyclic ring may be optionally fused to an aryl or heteroaryl ring； and wherein one or more carbon atoms of a group R1 and / or R2 may be optionally substituted by one or more halogen atoms； R3 represents H or - (CO) x-alkyl； R4 represents H or OH； R5 represents H, OH or>； = O； n represents a single or double bond with the proviso that when n represents a double bond R4 represents H； m represents a single or double bond with the proviso that when m represents a double bond R5 represents H； and x represents 0 or 1； including any tautomer thereof； or an isomer thereof in which the C>； = C bond in C26, 27 shown as trans is cis； and including a methanol adduct thereof in which a ketal is formed by combining the keto groups in C-53, if present, and hydroxyl in C-15 and methanol.Compuesto según la fórmula (I) a continuación, o una sal farmacéuti
