SAMPSON, PETER BRENT,LL, SZE-WAN,LIU, YONG,PAULS, HEINZ W.,EDWARDS, LOUISE G.,FORREST, BRYAN T.,FEHER, MIKLOS,PATEL, NARENDRA KUMAR B.,PAN, GUOHUA
申请号：
ES10761154
公开号：
ES2465971T3
申请日:
2010.04.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, in which: ring A is optionally substituted with one or more substituents represented by Ra and ring B is optionally and independently substituted with one or more substituents represented for Rb； ring C is a 5-membered heteroaromatic ring in which one of X1-X3 is N, one of X1-X3 is NR5, and one of X1-X3 is N or CR6； Y is independently N or CH or CRa； each of Ra and Rb 10 is independently: halogen, -C (O) OR1, -C (O) R1, -C (S) R1, -OC (O) R1-, -C (O) NR1R2, -C (S) NR1R2, -OC (O) NR1R2, -S (O) R1, -S (O) 2R1, -SO3R1, -SO2NR1R2, -OR1, -SR1, -NR1R2, -NR2C (O) R1, -NR2S (O) R1, -NR2C (O) OR1, -NR2C (O) ONR1R2, -N (R2) C (O) NR1R2, -NR2S O2NR1R2, -NR2SO2R1； -NO2, -CN, -NCS； or two ortho Ra groups taken together form -O- [CH2] p-O-, -S- [CH2] p-S- or - [CH2] q-； or C1-10 aliphatic group optionally substituted with one or more substituents selected from the group consisting of halogen, nitro, cyano, -N (R21) 2, -C (O) N (R21) 2, -C (O) N ( R21) 2, -NR21C (O) R21, -SO2R22, -SO2N (R21) 2, -NR21SO2R22, -NR21C (O) OR21, -OC (O) N (R21) 2, -NR21C (O) N (R21 ) 2, -NR21C (O) N (R21) 2, -NR21SO2N (R21) 2, -OR21, -SR21, C1-10 haloalkoxy, -C (O) R21, -C (O) OR21 and -OC (O ) R21； or (C0-10 alkylene) -Ar1, (C2-10 alkenylene) -Ar1, wherein Ar1 is a C6-14 aryl group or a 5-14 membered heteroaryl group, each optionally and independently substituted with one or more substituents selected from the group consisting of halogen, nitro, cyano, C1-10 alkyl, C1-10 haloalkyl, (C1-10 haloalkoxy) C1-10 alkyl, (C1-10 alkoxy) C1-10 alkyl, C1-10 hydroxyalkyl, C1-10 aminoalkyl, (C1-10 alkylamino) C1-10 alkyl, (C1-10 dialkylamino) C1-10 alkyl, -N (R21) 2, -C (O) N (R21) 2, -C (O) N (R21) 2, -NR21C (O) R21, -SO2R22, -SO2N (R21) 2, -NR21SO2R22, -NR21C (O) N (R21) 2, -NRC (O) ON (R) 2, -NR21SO2N (R21) 2, -OR21, -SR21, C1-10 haloalkoxy, -C (O) R21, -C (O) OR21, -OC (O) R21, 5-6 membered phenyl and het
