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苯並雜環衍生物及包含其的醫藥組合物
专利权人:
LTD.;TAIWANJ PHARMACEUTICALS CO.
发明人:
YANG, SYAULAN S.,杨 笑岚,楊 笑嵐,LEE, KUANG-YUAN,李广元,李廣元,LIU, MENG-HSIEN,刘孟宪,劉孟憲,JIANG, YAN-FENG,江彦锋,江彥鋒,FAN, YU-SHIOU,范宇琇,CHEN, CHI-HAN,陈錡翰,陳錡翰,LIU, SHENG-HUNG,刘胜紘,劉勝紘
申请号:
TW107131624
公开号:
TW201925154A
申请日:
2018.09.07
申请国别(地区):
TW
年份:
2019
代理人:
摘要:
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I):;is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or -C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, -NRy1Ry2, -ORy1, -Ry1C(O)Ry3, -C(O)Ry1, -C(O)ORy2, -C(O)ORy2Ry3, -NRy1C(O)Ry2, -NRy1C(O)NRy2Ry3, -NRy1C(O)ORy2Ry3, -NRy1C(O)Ry2ORy3, -C(O)NRy1(Ry2Ry3), -C(O)NRy1(Ry2ORy1), -ORy2Ry3, and -ORy2ORy3, wherein each of Ry1and Ry2is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and Ry3is aryl optionally substituted with at least one halogen; Z is -NRz1Rz2, -NRz1Rz3, -ORz1, -ORz1Rz3, -C(O)Rz1Rz3, -C(O)ORz1Rz3, -NRz1C(O)Rz2Rz3, -NRz1C(O)ORz2Rz3, -C(O)NRz1Rz3, or ORz2ORz3, wherein each of Rz1and Rz2is independently selected from a group consisting of H, oxygen, alkyl and aryl, and Rz3is aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, -RzaCOORzb, -ORzaCOORzb, -RzaSO2Rzb, -RzaSO2NRzbRzcRzd, -RzaC(O)RzbRzc, -RzaC(O)NRzbRzcRzd, -RzaC(O)NRzbSO2Rzc, wherein Rzais nil or alkyl, Rzbis H or alkyl, each of Rzband Rzcis independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NRzbRzcis a nitrogen-containing heterocyclic alkyl ring, Rzdis nil or a sulfonyl alkyl group.本發明提供一式(I)苯並雜環衍生物:;為一單鍵或雙鍵;n為0或1的整數;A為-CH2-、-CH(OH)-、或-C(O)-;G為碳或氮;X為-CH2-、氧、或-C(O)-;Y為選擇性地以至少一取代基取代之烷基、芳基、或雜環烷基,該取代基獨立地選自於由下列基團組成之群組:氫、鹵素、烷基、至少一鹵素取代之烷基、芳基、至少一鹵素取代之芳基、-NRy1Ry2、-ORy1、-Ry1C(O)Ry3、-C(O)Ry1、-C(O)ORy2、-C(O)ORy2Ry3、-NRy1C(O)Ry2、-NRy1C(O)NRy2Ry3、-NRy1C(O)ORy2Ry3、-NRy1C(O)Ry2ORy3、-C(O)NRy1(Ry2Ry3)、-C(O)NRy1(Ry2ORy1)、-ORy2Ry3、及-ORy2ORy3,其中Ry1與Ry2之每一者係獨立地選自於由氫、氧、烷基、及芳基組成之群組,且Ry3為選擇性地以至少一鹵素取代之芳基;Z為-NRz1Rz2、-NRz1Rz3、-ORz1、-ORz1
来源网站:
中国工程科技知识中心
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