ＢＥＴ蛋白抑制性二氫吡啶并吡酮农业专利-农业学术服务平台

发明人:: SCHMEES, NORBERT,史奇米　诺伯特,史奇米　諾伯特,BADER, BENJAMIN,贝德　班杰明,貝德　班傑明,HAENDLER, BERNARD,韩德勒　伯纳德,韓德勒　伯納德,STOCKIGT, DETLEF,施焦度　德特勒夫,LEJEUNE, PASCALE,雷朱尼　帕斯卡尔,雷朱尼　帕斯卡爾,FERNANDEZ-MONTALVAN, AMAURY ERNES,史奇米诺伯特,史奇米諾伯特,贝德班杰明,貝德班傑明,韩德勒伯纳德,韓德勒伯納德,施焦度德特勒夫,雷朱尼帕斯卡尔,雷朱尼帕斯卡爾

摘要：: The present invention relates to BET protein-inhibitory, especially BRD4-inhibitory, dihydropyridopyrazinones of the general formula (I) in which A, X, R1, R2, R3, R4, R4, R6, R7 and n have the meanings given in the description, to intermediates for preparation of the compounds according to the invention, to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of neoplastic disorders. This invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.本發明係關於BET蛋白抑制性，尤其BRD4抑制性通式(I)之二氫吡啶并吡酮，其中A、X、R1、R2、R3、R4、R5、R6、R7及n具有說明書中指定之含義；用於製備本發明化合物之中間物；包含本發明化合物之醫藥組合物；及其在過度增生性病症之情況下，尤其在贅生性病症之情況下的預防及治療用途。本發明進一步關於BET蛋白抑制劑在病毒感染、神經退化性病症、發炎疾病、動脈粥樣硬化病症及雄性生育力控制中之用途。