The present invention relates to BET protein-inhibitory, especially BRD4- inhibitory, dihydroquinoxalinones and dihydropyridopyrazinones of the general formula (I) in which A, X, R1, R2, R3, R4, R5, R6 and n are each as defined in the description, to intermediates for preparation of the inventive compounds, to pharmaceutical compositions comprising the inventive compounds, and to the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of neoplastic disorders. This invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.本發明係關於通式(I)之具BET蛋白抑制性、尤其BRD4-抑制性之二氫喹啉酮及二氫吡啶并吡酮，其中A、X、R1、R2、R3、R4、R5、R6及n各自係如說明書中所定義；用於製備該等本發明化合物之中間體、包括該等本發明化合物之醫藥組合物及其在過度增殖性病症情形下，尤其在腫瘤病症情形下之預防性及治療性用途。本發明另外係關於BET蛋白抑制劑在病毒感染、神經退化性病症、發炎疾病、動脈粥樣硬化病症及男性生育控制中之用途。
