What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3- benzodiazepines of the general formula (I) in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.本發明闡述具有BET蛋白抑制性，特定而言BRD4抑制性之通式(I)之2,3-苯二氮呯：其中R1a、R1b、R1c、R2、R3、R4、R5、A及X具有說明中提出之含義；用於製備該等本發明化合物之中間體；包括該等本發明化合物之醫藥組合物；及其用於過度增殖性病症，特定而言用於腫瘤病症之預防性及治療性用途。亦闡述BET蛋白抑制劑用於以下之用途：良性增生、動脈粥樣硬化病症、敗血症、自體免疫病症、血管病症、病毒感染、神經退化性病症、發炎性病症、動脈粥樣硬化病症及控制男性生育。
