SCHMEES, Norbert,HAENDLER, Bernard,STCKIGT, Detlef,GALLENKAMP, Daniel,BISSELL, Richard, Alexander,BOUGLAS, Richard, Alexander
申请号：
HK16109965.4
公开号：
HK1221721A
申请日:
2016.08.22
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention relates to BET protein-inhibitory, especially BRD4-inhibitory, dihydroquinoxalinones and dihydropyridopyrazinones of the general formula (I) in which A, X, R1, R2, R3, R4, R5, R6 and n are each as defined in the description, to intermediates for preparation of the inventive compounds, to pharmaceutical compositions comprising the inventive compounds, and to the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of neoplastic disorders. This invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.
