Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.本發明提供式(I)之經取代之異吲哚啉酮,製備此等化合物之方法,包含此等化合物之醫藥組合物及藥劑,及使用此等化合物治療或改善與蛋白質功能失常相關之疾病、病症或病況(諸如癌症)的方法。