The present invention relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease.本發明係關於經取代的雜環衍生治療用化合物、包含該等化合物之組合物、及該等化合物及組合物藉由抑制對蛋白質諸如組織蛋白之乙醯基離胺酸區域之布羅莫結構域介導之識別而用於表觀遺傳調控之用途。該等組合物及方法係用於治療由異常細胞信號傳導介導之疾病，諸如發炎性病症、癌症及腫瘤病。
