溴結構域(BROMODOMAIN)抑制劑农业专利-农业学术服务平台

发明人:: BENNETT, MICHAEL JOHN,班奈特　麦可　约翰,班奈特　麥可　約翰,BETANCORT, JUAN MANUEL,贝坦寇特　裘安　曼努尔,貝坦寇特　裘安　曼努爾,BOLOOR, AMOGH,波罗尔　艾莫格,波羅爾　艾莫格,KALDOR, STEPHEN W.,卡尔多　史蒂芬Ｗ,卡爾多　史蒂芬Ｗ,STAFFORD, JEFFREY ALAN,史戴佛　杰佛瑞　艾伦,史戴佛　傑佛瑞　艾倫,班奈特麦可约翰,班奈特麥可約翰,贝坦寇特裘安曼努尔,貝坦寇特裘安曼努爾,波罗尔艾莫格,波羅爾艾莫格,卡尔多史蒂芬W,卡爾多史蒂芬W,史戴佛杰佛瑞艾伦,史戴佛傑佛瑞艾倫

摘要：: The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.本發明係關於經取代之雜環衍生物化合物、包含該等化合物之組合物及該等化合物及組合物藉由抑制溴結構域介導的諸如組蛋白之蛋白質之乙醯基離胺酸區域識別而進行表觀遺傳調控的用途。該等組合物及方法適用於治療癌症及贅生性疾病。