BENNETT, MICHAEL JOHN,班奈特麦可约翰,班奈特麥可約翰,BETANCORT, JUAN MANUEL,贝坦科特胡安曼努尔,貝坦科特胡安曼努爾,BOLOOR, AMOGH,柏卢尔阿莫克,柏盧爾阿莫克,KALDOR, STEPHEN W.,卡尔多史蒂芬W,卡爾多史蒂芬W,STAFFORD, JEFFREY ALAN,史塔福德杰佛瑞艾伦,史塔福德傑佛瑞艾倫,VEAL, JAMES M
申请号：
TW105111879
公开号：
TW201643153A
申请日:
2016.04.15
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.本發明係關於經取代之雜環衍生物化合物、包含該等化合物之組合物,及該等化合物及組合物藉由抑制溴結構域介導之諸如組蛋白之蛋白的乙醯基離胺酸區域識別而用於表觀遺傳調控之用途。該等組合物及方法適用於癌症及贅生性疾病之治療。
