HEYES, JAMES,HOLLAND, RICHARD J.,JUDGE, ADAM,LEE, AMY C. H.,MARTIN, ALAN D.,SNEAD, NICHOLAS MICHAEL,THI, EMILY P.,WOOD, MARK,YE, XIN
申请号：
CA3059426
公开号：
CA3059426A1
申请日:
2018.04.10
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
