Methods related to the development and use of these compounds, pharmaceutical ingredients containing these compounds, and modulation methods of G12C variant hormone activity for treating diseases such as cancer are also provided. 1. Property 1: compound (1) with formula structure property,a、 Or a salt, isotopic form, stereoisomer or pharmaceutically acceptable production, wherein: 1 and g s are independent N or CH； 1 is a link to O-NR83099；L2 is a connection or lease； X, y and Z are independent n or Cr '；R's, in each substance, is independent of ammonia, cyanogen, hydroxy and hydrocarbon c83321316262；1. C83228331 asphalt；Halogenated tar c83321531832626,Hidroxilalquilo C83221；Cianoalquilo C83217C8331832626；Alcoxi, aminilalquilo, aminilalquiloxi, aminilalquinilo, alcoxicoquiloxi, alcoxicoquinio, acelcarboonilaminil, aminilalquilo, aminilalquilo, cyclolalquilo, cyclolalquilo, heterosexual, isocyclopentadiol, isocyclopentadiol, arilo, aralquilo, isopropenediene, isopropenediene nitrile； - nr7491； - r749595；C83217c83331832626 hydrocarbon1. No. c83217c83331832626 oil layer；a. R 74919 was h or c832131；e. R'sea h-cn, X and Z are all N, R1 adopts formula structure (2)；Each "tip ring" represents an aromatic ring； A1,...A3 and a830808 are C or n respectively； B1 is n, NH, C (= O),2.Crís 7497；This is n, NH, C (= O)2. Cr ° 758484 or NR ° 75848 '；B3 is n, NH, C (= O)2. Cr ° 750101 or NR ° 750101 '；One r74919,R74959,R1 758080 and R1 74969 are one with *,Another r74919,R74959,R1 758080 and R1 74969 are h, amino, Ciano, halo, hidroxilo, acquilo c83218331 and r832626, respectively；Alquenilo C83228331-832626；1. C 83228331 asphalt；Rental, halide c833218331832626,Alcoxi C832188331636262；a.Halocalcoxi C8321；1.cycloquilo，heatcyclo，aminilalquilo，cianoal quilo C832121833183226；Carboxialquilo C83217C8331832626；1. Calcium carbonate or carbides； R1 74977；R7 758484 and R7 750101 are h, amino, Ciano, halo, hidroxilo, acquilo c83218331 and r832626, respectively；Alquenilo C8321218D8331-832626；1. C
