1. Claim 1: a formula compound (1),Or any form of stereoisomerization, where het is an alien with any formula,(3)(4)(5)；Each x is independent of C or N； provided that at least 2 x is C； each r749191 group,R74959,R7 758080 or r74966 is independent of H, halogen and c832131；C₃₋₇ cycloalkyl,C₁₋₆ alkyloxy,N (R)CO (R)CH₂NH₂,Ch8322； Oh, CN, C (= Noh) nh832222；C (3DNOCH) NHC (3DNH) NHCf.8323 and ocf8323；e. When X atom is connected with N, rs7495o or r74966 is not present； each R2 is - (cr831222； r8313)； - r183440404；m is an integer from 0 to 6； each R³ is independently selected from the group consisting of H, halogen, aryl, heteroaryl, C₁₋₆ alkyl,C₃₋₇ cycloalkyl,c. C83321xi-8331-832626 and CO (r8311811)；each R⁶ is independently selected from the group consisting of H, C₁₋₆ alkyl,Cooch83323 and conhso 83222； ch832323；each R⁷ is independently selected from the group consisting of H, C₁₋₆ alkyl,OH, C₁₋₆ alkyloxy,NH.8322；Nhso8322jn (lease c8321) 833231；NHSO₂NHCH₃,NHSO₂ (C₁₋₆ alkyl),NHSO₂ (C₃₋₇ cycloalkyl) and N (C₁₋₆ alkyl) ₂,No. 8312； r8313 and 8313； R1 830404；each R⁸ and R⁹ is independently selected from the group consisting of H, C₁₋₁₀ alkyl and C₃₋₇ cycloalkyl；O r831222 and r8313；Each r83044 is independent of H, halogen group, oh, CN, CF 83222； h, CF 8323； and；1. Lease land No. c833218331 and 832626；C₃₋₇ cycloalkyl,C O q C)C (3DO) (cicloalquilo C)C (= O) No. 831222； r8313,C (3DO) ORSO₂R⁸,C (3DO) N (R) SO RC (3DO) N (R) SO N (R R)8312； 8313；No. 8312； (= O) or8313；OC (3DO) RO-benzene, No. 831222； so8322； r8313；SO NR RSO₂R⁸,OC (3DO) NR ROC (3DO) NR RN (R) C (3DO) N (R R)R1,N (R) C (3DO) OROr1,C (= O) R1 and a saturated ring composed of 4 to 6 members, containing oxygen atoms； R1 is phenyl, pyridine or pyrazolate； each of them can be replaced by one or more substitutes independent of the CF 8323 group；Ch8323,$8.8323OCF₃ and halogen； R¹² is C₁₋₆ alkyl or C₃₋₇ cycloalkyl each substituted with one or more substituents each independently selected from the group consisting of CF₃,C
