DAVID R. LANCIA JR.,NICHOLAS BARCZAK,XIAOZHANG ZHENG,BINGSONG HAN,ALEKSANDRA RUDNITSKAYA,DAVID S. MILLAN,KENNETH W. BAIR,HEATHER DAVIS,PUI YEE NG
申请号：
ARP160101057
公开号：
AR104306A1
申请日:
2016.04.18
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. Claim 1: a formula compound (1),Or one of the salts, stains, solutions, hydrates, ceramics or isomers, where:X2,X3,X8310 and x8311 are independent, respectively, CR1,- he...- that is...-C (O) --SO₂-,-S (O) - o -S-X83088 and x83099 are independent, respectively, CR1,-C (O) --SO₂-,-S (O) - o -S-Y1,Y3 and y830808 are n or CR1 respectively；L is a link, - (CR1 2)-C (O) NR --S (O) --S (O) NR --S (O) --S (O) NR --C (O) (CR R) O- o -C (O) (CR R) -R is independently -H, -alkyl C₁₋₆,C₂₋₆ alkenyl,-cycloalkenyl Cque,-alkynyl C₂₋₆,-cycloalkyl C₃₋₈,-spirocycle C₅₋₁₂,heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, oxo, -NO₂,-CN, R1,-R-SRO,-Orc,-NHRC,-R83088；-S (O) NR R-S (O) R-C (O) R-CO₂R¹,-NR S (O) R-S (O) R-S (O) NR R-NR S (O) RHeterosexual, arilo or heterosexual； R1 and R2 are independent in each case, h, R3,-R83088,-Apartment No. 83318326, No. c832183,-alkenyl C₂₋₆,-cycloalkenyl Cque,-alkynyl C₂₋₆,-cycloalkyl C₃₋₈,1. Isopropyl, isopropyl, isopropyl, containing 1-5 heteroatoms selected from n, s, P and O groups；-CN, -NH-C₁₋₆-alkyl,-N (C₁₋₆ alkyl) ₂,-S (O) ₂N (C₁₋₆ alkyl) ₂,-N (alquil C) S (O) R-S (O) ₂ (C₁₋₆ alkyl),- (alquil C) S (O) R-C (O) alquilo C-CO₂-alkyl Cilo,-N (C₁₋₆-alkyl) S (O) ₂-C₁₋₆-alkyl or (CHR⁵) ₙNR³R⁴,There, each tar, aluminum, cyclopentadiene, tar, cyclopentadiene, isopropene, arilo or isopropene can be replaced with one or more - Oh, halogen, no832222；oxo -CN -R-Orc,-NHRC,NR³R⁴,-S (o) 8322； (r cube) 8322 -,-S (O) R-C (O) R-CO₂R⁵,-NR S (O) R-S (O) R-S (O) NR R-NR S (O) RHeterocycle, arilo or heterocycle； or R1 and R2 can be combined with carbon atoms to form a cyclopentyl, heterocycle, helix, helix isomerization or epoxyphosphoryl； or R1 and R2,when on adjacent or non-adjacent atoms, they ca
