CHEN, LIBING,WALKER, STEVEN J.,HARIKRISHNAN, LALGUDI S.,KAMAU, MUTHONI G.,PARK, PETER KINAM,QIN, LAN,YING - RUAN, ZHEMING,ZHAO, YUFEN,DODD, DHARMPAL S.,FINK, BRIAN E.
申请号:
ARP190100352
公开号:
AR114369A1
申请日:
2019.02.13
申请国别(地区):
AR
年份:
2020
代理人:
摘要:
Periodic butyric acid, understanding their drug synthesis, and using them to treat various cancers and leukemia. 1. Claim 1: a compound characterized by formula (1),Where x is independent or s; x1,X2,X3 ° and X ° 830808 are independent, or NH; R1 and R2 are independently selected from the formula group (2);2. If R1 and R2 compounds are selected from the formula group (3);Z1 is n or cr74919;Z is No. 74955;R7491es h, halogen, c83321833183838326 tar replaced by 0-6 r83099;C8332383318c8326cycloqui was replaced by 0-6 r83099;CN,No.832222,Oh, or7491; 1,SR7491;1,-C(O)NR 7491;R7491;1,-Coor7491 1,-OC(O)R7491;-OC(O)NR7491;R7491;1,-7491; - 74191; - 1,-No. 7491; - 1 C (o) r7491; - 1-7491; - coor749191,-7491; - 1 C (o) No. 7491; - 1 r7491;-No. 7491; 1 s (o) 8322; r7491; 1,-No. 7491; - S (o) 8322; - No. 7491;; No. 1 r7491; - No. 1;-S(O)R7491;-S(O)NR 7491;R7491;1,-S(O)8322;R7491;1,S(O)8322;NR7491;1;R7495es h, c83218331832626 asphalt replaced by 0-6 r83099;C8332383318c8326cycloqui was replaced by 0-6 r83099;-C(O)R7491;-C(O)NR 7491;R7491;1,-S(O)8322;R7491;1 O(O)8322;NR7491;1 R7491;R7491;1 ES H,C83218331;Halogo,-NR 7491;;1 R7491;;1 O Or7491;;1R3 ° 7491 is h, ch8323;Halogo,-Nr.7491;;1 R7491;;1 U Or7491;;1O r 3 and R 3 7491 can be taken together to form 3 or 4 members of thyroid; or R3 and R3 7491 can be taken together to form a substitute for C = ch832222;R8309es h, halogen, c833218331832323 for rent, CN, no8322;Oh, or7491; 1,SR7491;1,-C(O)NR 7491;R7491;1,-Coor7491 1,-OC(O)R7491;-OC(O)NR7491;R7491;1,-7491; - 74191; - 1,-No. 7491; - 1 C (o) r7491; - 1-7491; - coor749191,-7491; - 1 C (o) No. 7491; - 1 r7491;-No. 7491; 1 s (o) 8322; r7491; 1,-No. 7491; - S (o) 8322; - No. 7491;; No. 1 r7491; - No. 1;-S(O)R7491;-S(O)NR 7491;R7491;1,-S(O)8322;R7491;1 O(O)8322;NR7491;1 R7491;O two r83099 can form a nonperiodic or carbon based group of 5 or 6 members together; or r83099; r7491h or c83183318323 asphalt; r8310h, halogen, c8321833323lo, CN, no228383838310; r83099; r7491h or c83183318323 asphalt