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Binary Compounds as ATX Inhibitors
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
DI GIORGIO, PATRICK,SCHMITZ, PETRA,RUDOLPH, MARKUS,MATTEI, PATRIZIO,HUNZIKER, DANIEL,HERT, JRME
申请号:
ARP180100600
公开号:
AR111524A1
申请日:
2018.03.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
It includes the composition of the compound and the method of using the compound. 1. Requirement 1: Select the compounds (1) and (2) of R1 from the category consisting of (1) phenyl substituted with r3.R83088 and R83099;(2) Phenyl-C8321C 8331832626, replaced by r3;R83088 and R83099;(3) Phenyl-C8321C 83318326 was replaced by r3;R83088 and R83099;(4) Phenyl-Alquenilo C83222C 833318326 was replaced by r3;R83088 and R83099;(5) Replace phenyl-asphalt C832283318326 with r3;R83088 and R83099;(6) substituting pyridine with r3,R83088 and R83099;(7) Pyridine-grass C83218331832626;R83088 and R83099;(viii) Piridini-Alquenilo C832283331;R83088 and R83099;(9) Pyridine-asphalt C832283331; 832626;R83088 and R83099;(x) substituting sulfur and phosphorus with r3;R83088 and R83099;(11) Tiofenil-asphalt C83218331832626;R83088 and R83099;(12) Tiofenil-Alquenilo C832283331 and 832626;R83088 and R83099;(13) Tiofenil-bitumen C832283331 and 832626, replaced by r3;R830808 and R83099;From the (i) - OC (o) group,2-C(o) -;A is selected from a group consisting of (1) or (2).(2) S-;X is selected from a group of (i) - n -.(y) II--W is selected from a group consisting of (i) - C (o).(y) 2S (o) 8322-;R2 is selected from the ring system or from AO, Aw, AX, AY and AZ of the formula group (3);R3 unites were selected from (i) halogen, (i) hydroxyl, (i) cyanide, alkyl C832183832626 and other substances.Four Alcoxi C83218d 8331832626;(v) Alcox C83217D.833183226-Rent C83218D.83312626;Six Halo-Alcoxi C83218331832626;(vii) Halo-Acquilo C8321C 8331832626;(8) Hidroxi - C8321833126;Nine Cycloal Quilo C83323318328;(x) cyclokquil C832-833318328;(xi) cyclokquil C83223-83331;(12) Cycloalcoxi C8323-83318328;(13) Cycloalcoxi C832-833318328;(14) C83218C83318326; (XV) Acquil C8321838326; (Carboniamino, XVI) cycloquil C8383331; (XVII) Acquil CC283318326; (XVIII) C8321833226; (Tetrazolil-Acquilo C83218383326283; (XVI) cycloquil C83833333 331; (XVIII) Acquil CC283318326; (XVIII) Tetrazolil-Acquil C8331833226; (XVI) cycloq
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