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Sulfur-Pyridine Compound 1 Substituted for Malta Inhibitor
专利权人:
LUPIN LIMITED
发明人:
KUKREJA, Gagan,IRLAPATI, Nageswara Rao,JAGDALE, Arun Rangnath,DESHMUKH, Gokul Keruji,VYAVAHARE, Vinod Popatrao,KULKARNI, Kiran Chandrashekhar,SINHA, Neelima,PALLE, Venkata P.,KAMBOJ, Rajender Kumar
申请号:
PE2019000282
公开号:
PE20190656A1
申请日:
2017.07.28
申请国别(地区):
PE
年份:
2019
代理人:
摘要:
With regard to the substituted sulfur-pyridine (I) compounds,R1 was selected from H, halogen, cyanide, R2 from asphalt, substituted asphalt, cyclopentadienol, R3 from heterogeneous, substituted heterosexual, Arilo and so on. One of the selected compounds is 1-(5-chloro-6-methoxypyridine-3-i) -3-(7-cyclopropyl-2-methylthiazole [5,4-B] pyridine-6-il) urea. In addition, it refers to the use of it as an inhibitor of Malta for the treatment of inflammatory and autoimmune diseases or diseases, such as cancer, and for the synthesis of these compounds and the pharmacological components containing them.Referido a compuestos de tiazolo-piridina sustituida, de formula (I), en el que R1 se selecciona de H, halogeno, ciano, entre otros; R2 se selecciona de alquilo, alquilo sustituido, cicloalquilo, entre otros; R3 se selecciona de heteroarilo, heteroarilo sustituido, arilo, entre otros. Un compuesto seleccionado es 1-(5-cloro-6-metoxipiridin-3-il)-3-(7-ciclopropil-2-metiltiazolo[5,4-b]piridin-6-il)urea. Ademas, se refiere a su uso como inhibidores de MALT1 en el tratamiento de enfermedades o trastornos inflamatorios y autoinmunes, como el cancer; metodos para sintetizar dichos compuestos y composiciones farmaceuticas que los contiene.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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