PROBLEM TO BE SOLVED: To provide a coated particle in which a bioactive substance having an average particle diameter of 10 to 3000 μm is allowed to have a pH responsive eluting property while using only food materials by using an alginate.SOLUTION: In order to solve the above-mentioned subject, the present invention provides a pH responsive eluting coated granulated material having a coat layer of an alginate (A) consisting of the following alginates (A1) and (A2), on the periphery of a core (S) containing a bioactive substance, the pH responsive eluting coated granulated material having a mass ratio of the core (S)/alginate (A) of 50/50 to 97/3 and having a mean particle size of 10 to 3000 μm. Alginate (A1): an alginate in which the viscosity of 1 mass% aqueous solution at 20°C is 20 to 1000 mPa s. Alginate (A2): an alginate in which the viscosity of 1 mass% aqueous solution at 20°C is less than 20 mPa s.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】本発明の課題は、アルギン酸塩を使用することで食品素材のみを用いながら、平均粒子径が10~3000μmの生理活性物質にpH応答溶出性をもたせた被覆粒子を提供することにある。【解決手段】上記課題を解決するために、生理活性物質を含有する芯材(S)の外周上に、下記のアルギン酸塩(A1)、(A2)からなるアルギン酸塩(A)の被覆層を有するpH応答溶出性被覆造粒物であって、芯材(S)/アルギン酸塩(A)の質量比が50/50~97/3であり、平均粒子径が10~3000μmであるpH応答溶出性被覆造粒物を提供する。アルギン酸塩(A1):20℃における1質量%水溶液の粘度が20~1000mPa・sとなるアルギン酸塩アルギン酸塩(A2):20℃における1質量%水溶液の粘度が20mPa・s未満となるアルギン酸塩【選択図】なし
