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Use of taurolidine or taurultam for the manufacture of a medicament for the treatment of tumors
专利权人:
GEISTLICH PHARMA AG
发明人:
CALABRESI, PAUL,DARNOWSKI, JAMES,COSTIN, JAMES
申请号:
ES10012266
公开号:
ES2531547T3
申请日:
2000.12.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound selected from taurolidine or taurultam for use in a method selected from: (i) a method for inducing apoptotic death of a neoplastic cell, which comprises contacting said cell with an amount inducing apoptosis of said compound ; (ii) a method for inducing apoptotic death of a neoplastic cell, comprising contacting neoplastic cells and normal cells with said compound at a concentration sufficient to induce the death of said neoplastic cells preferably against said normal cells; (iii) a method for inhibiting the growth of an autologous neoplastic cell in a mammal, comprising administering to said mammal a composition comprising said compound; (iv) a method for inhibiting the growth of a drug resistant neoplastic cell in a mammal, comprising administering to said mammal a composition comprising said compound; (v) a method for killing a neoplastic cell in a mammal, which comprises administering to said mammal a composition comprising said compound, and wherein said composition is administered so that it directly contacts the surface of said neoplastic cell a a dose sufficient to induce the death of the neoplastic cell by apoptosis; (vi) a method for purging a population of bone marrow cells from ex vivo neoplastic cells, comprising contacting said population with a composition comprising said compound; wherein said neoplastic cells is a tumor selected from the group consisting of breast cancer, prostate cancer, pancreatic cancer, lung cancer and gastric cancer.Un compuesto seleccionado de la taurolidina o el taurultamo para su uso en un método seleccionado de: (i) un método para inducir la muerte apoptótica de una célula neoplásica, que comprende poner en contacto dicha célula con una cantidad inductora de la apoptosis de dicho compuesto; (ii) un método para inducir la muerte apoptótica de una célula neoplásica, que comprende poner en contacto células neoplásicas y células normales con dicho compuesto a una concentración suficiente para inducir la muerte de di
来源网站:
中国工程科技知识中心
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