PURPOSE: A mushroom cultivation method using food and drink waste compost is provided to improve the hypha growth efficiency of mushrooms by using nutrients inside the food and drink waste compost. CONSTITUTION: A mushroom cultivation method using food and drink waste compost comprises the following steps: producing the compost using food and drink waste; mixing the obtained compost with medium ingredients to obtain a mixed medium; adjusting the moisture content of the mixed medium into 60-65wt%; sterilizing the obtained culture medium; injecting mushroom spawns into the sterilized culture medium, and cultivating mycelia; and growing the mycelia into fruit bodies. The medium ingredients include rice bran, sawdust, waste cotton, cotton seed husk, rice straws, and other ingredients. The mixed medium contains more than 5wt% of food and drink waste compost.본 발명은 음식물류 폐기물을 퇴비화하여 얻어진 음식물 퇴비를 쌀겨, 톱밥, 폐면, 면실피, 볏짚, 콘코프, 사탕수수, 비트펄프 및 면실박으로 이루어진 군에서 선택된 하나 이상의 배지 원료에 첨가하여 얻어진 버섯 재배 배지에 버섯 균주를 접종하여 버섯을 재배하는 것을 특징으로 하는 버섯 재배 방법을 개시한다.