DERIVES DE PYRAZOLE TRICYCLIQUE ET LEUR UTILISATION COMME MODULATEURS DES RECEPTEURS CB1 OU CB2

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专利权人:

NEUROSCIENZE PHARMANESS S.C. A R.L.

发明人:

LAZZARI, PAOLO,RUIU, STEFANIA,PINNA, GERARD AIME,MURINEDDU, GABRIELE

申请号：

CA2507710

公开号：

CA2507710C

申请日:

2005.05.17

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: (see formula I) wherein: A represents a group selected from one of the following: (CH2) t-, -(CH2) -S (O) z-, or -S (O) z-(CH2)-, - B is a heteroaryl, optionally substituted； - R is a group selected from the following: - alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other； - R' is a group selected from the following: - an ether group of formula - (CH2) -O- (CH2) v-R", - a ketonic group of formula -C (O) -Z' , wherein Z' is as defined below； - a substituent having an hydroxyl function of formula -CH (OH) -Z'； - an amide substituent of formula -C(O)-NH-T'.

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