Thomas, Andrew,Buettelmann, Bernd,Jakob-Roetne,Roland,Lucas, Matthew C.,Knust, Henner
申请号：
AU2013203735
公开号：
AU2013203735A1
申请日:
2013.04.11
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013203735A120130502.pdf#####ISOXAZOLO-PYRIDINE DERIVATIVES Abstract 5 The present invention is concerned with isoxazole-pyridine derivatives of formula (I) wherein X is 0 or NH R1 is phenyl, pyridinyl, or pyrimidinyl, each optionally substituted with 1, 2 or 3 halo, R2 is H or CH 3 or CF3 R3, R4, R and R6 are each independently H optionally substituted Ci_7alkyl optionally substituted Ci_7alkoxy CN, 10 halo, NO2 , S-Ci_7alkyl, S(O)-Ci_7alkyl optionally substituted benzyloxy -C(O)-Ra, -C(O)NR R , or a pharmaceutically acceptable salt thereof. The compounds are active on the GABA A c5 receptor binding site and useful for the treatment of cognitive disorders, such as Alzheimers disease.
