A compound of the formula in which X is -Cl, -F or -Br； X 'is hydrogen or -F； V is -F, -Cl or -Br； V 'is hydrogen or -F； Y is hydrogen, methyl, methoxy, -F or -Cl； W is -F, -Cl, -Br, -I, ethynyl or isopropenyl； A is -O-, -NH-, -CH2-, -C (= O) -, -C (= O) NH-, -NHC (= O) -or -NHS (= O) 2-； B is a bond or - (CH2) mCR1R2 (CH2) n-； m = 0 or 1； n = 0 or 1； R1, R2 are hydrogen or alkyl with 1 to 8 carbon atoms, and in the case where R1 and R2 can be linked independently to form a cyclic structure selected from a substituted or unsubstituted cycloalkyl； provided that if B is a bond, then R is selected from heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl, aryl, substituted aryl or substituted cycloalkyl； and if B is not a link, then R is selected from -OR ", -NR'R", -C (= O) NR'R ", -NHC (= O) R", -NHS (= O) 2R ", -NHC (= O) NR'R" or -C (= O) NR'S (= O) 2R ", and R ', R" is independently selected from the group consisting of hydrogen, lower alkyl , aryl, lower alkenyl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, cycloalkyl and substituted cycloalkyl, provided that R "is not hydrogen, and in the case where R 'and R", they can be joined together independent to form a cyclic structure selected from substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or substituted or unsubstituted heterocycle； and pharmaceutically acceptable salts, and enantiomers thereof.Un compuesto de fórmula en la que X es -Cl, -F o -Br； X' es hidrógeno o -F； V es -F, -Cl o -Br； V' es hidrógeno o -F； Y es hidrógeno, metilo, metoxi, -F o -Cl； W es -F, -Cl, -Br, -I, etinilo o isopropenilo； A es -O-, -NH-, -CH2-, -C(=O)-, -C(=O)NH-, -NHC(=O)-or -NHS(=O)2-； B es un enlace o -(CH2)mCR1R2(CH2)n-； m=0 o 1； n=0 o 1； R1, R2 son hidrógeno o alquilo con de 1 a 8 átomos de carbono, y en el caso en el que R1 y R2 puedan unirse de forma independiente para formar una estructura
