HA CHOI,JAMES SOON - LAJINESS,SRINIVASA NATALA,BAO NGUYEN,HANK MICHAEL JAMES PETRASSI,ZHICHENG WANG
申请号：
ARP150101470
公开号：
AR100418A1
申请日:
2015.05.13
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
This table provides the compounds (1) of the formula. This document also provides the pharmaceutical ingredients containing these compounds, as well as the methods of using these compounds to treat joint injury or joint injury in mammals, and the methods of inducing the separation of highland cells from the stems of condoms. 1. Claim 1: a formula compound (1),Or a pharmaceutically acceptable salt, or its stereoisomer, wherein -- is a simple or double connection； a is cr831222； r831222； 74955；No. 8313,O； in r831223； 74919；R⁸ᵇ and R⁹ are each independently hydrogen or C₁₋₆ alkyl；L is * -C (O) NR¹⁰- or * -C (O) O-,where * represents the point of attachment of L to the bicyclic ring containing A, and R¹⁰ is hydrogen or C₁₋₆ alkyl；R830404 is selected from hydrogen and tar；R1 is selected from halo, Ciano, C (o) R1,-C (O) NR R-C (O) ONR R5- and 6-membered heterocycloalkyl, 5- and 6- membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein R¹¹ is hydrogen or C₁₋₆ alkyl；R¹²ᵃ and R¹²ᵇ are each independently hydrogen or C₁₋₆-alkyl；the heterocycloalkyl, heterocyclyl, phenyl or heteroaryl of R¹ is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C₁₋₆-alkyl,haloalkyl C₁₋₆,-C (O) R-C (O) OR-8308； 7491； 8308； 7495；5- and 6-membered heterocycloalkyl, phenyl and 5- and 6-membered heteroaryl； where R¹³ is selected from hydrogen, C₁₋₆ alkyl,haloalkyl C₁₋₆,amino, and C₁₋₆ alkylamino；R8308；]-C (O) R-C (O) OR y -S (O) Rwhere R¹⁵ is hydrogen or C₁₋₆ alkyl；and the heterocycloalkyl, phenyl or heteroaryl substituent of R¹ is further substituted by 1 to 2 substituents independently selected from halo, C₁₋₆ alkyl,haloalkyl C₁₋₆,and hydroxyl； R³ is selected from C₁₋₆ alkyl,haloalkyl C₁₋₆,3 to 6 members (159)4-7 membered heterocycloalkyl, 5-10 membered heterocyclyl, phenyl, and 5-9 membered heteroaryl, wherein the R³ cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl is substituted or unsubstituted by 1 to 2 independently s
