It include that one or more layers include multiple monomers present disclose provides nucleic acid carrier, wherein each monomer includes: the first and second oligonucleotides Wherein,Each first oligonucleotides part is complemented each other, and double stranded region, two not complementary the second oligonucleotides of part of two first oligonucleotides of part are formed, to form four end arms It is bound at least one peripheral terminal arm at least one targeting agent, wherein as the miRNA of at least one targeting agent. The present invention also provides pharmaceutical composition, it includes any nucleic acid carrier, as described herein and pharmaceutically acceptable carrier. The disclosure induces the method for immune response in also providing, including gives the animal any nucleic acid carrier described herein.
