The pharmaceutical composition contains an agent which restricts the expression or activity of an antigen associated with a tumor. The antigen has a sequence, coded by a nucleic acid, where the nucleic acid or a sequence is from the group SEQ ID NOs: 19-21, 54-57, 1-5, 29, 31-33, 37, 39, 40, 62, 63, 70, 74, 85-88 as a part or derivative. It also has a nucleic acid which is hybridized with the nucleic acid/sequence group under stringent conditions, a nucleic acid which is degenerated, and a complementary nucleic acid.