LIM, Wendell A.,OKADA, Hideho,ROYBAL, Kole T.,CHOE, Joseph H.,WATCHMAKER, Payal B.
申请号：
AU2019249221
公开号：
AU2019249221A1
申请日:
2019.04.04
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Methods are provided for treating a subject for glioblastoma, including e.g., an EGFRvIII negative glioblastoma. The methods of the present disclosure involve administering to a subject a molecular circuit that includes a binding triggered transcriptional switch (BTTS) that binds to a priming antigen expressed by the subjects glioblastoma multiforme (GBM) that, when bound to the priming antigen, induces one or more encoded therapeutics specific for one or more antigens expressed by the GBM. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.
