LIM, Wendell A.,OKADA, Hideho,ROYBAL, Kole T.,CHOE, Joseph H.,WATCHMAKER, Payal B.
申请号：
AU2019249215
公开号：
AU2019249215A1
申请日:
2019.04.04
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Methods are provided for treating a subject for an EGFRvIII expressing glioblastoma. The methods of the present disclosure involve administering to the subject a molecular circuit that is primed by EGFRvIII to induce one or more encoded therapeutics specific for one or more antigens expressed by the glioblastoma. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.
