Charles Allerson,Balkrishen Bhat,Ann B. Eldrup,Muthiah Manoharan,Richard H. Griffey,Brenda F. Baker,Eric E. Swayze
申请号：
US14834224
公开号：
US09708610B2
申请日:
2015.08.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
