SONG, DAE HAE,SHIN, JAE HEE,PARK, YOUNG JIN,IM, DAE SEONG,BAE, SUNG MIN,KWON, SE CHANG
申请号：
EP11763093
公开号：
EP2552474A4
申请日:
2011.04.04
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
