INSTITUTO DE TECNOLOGIA E PESQUISA;UNIVERSIDADE ESTADUAL PAULISTA " JÚLIO DE MESQUITA FILHO";UNIVERSIDADE TIRADENTES
发明人:
DANIELE MARTINS DE LIMA,FABIANA MASAGO,LUCIANA NALONE ANDRADE,LUIZ CLAUDIO DI STASI,PATRÍCIA SEVERINO
申请号：
BR102017019855
公开号：
BR102017019855A2
申请日:
2017.09.15
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention patent (pi) concerns a process of obtaining nano and microparticles encapsulating 4 -methylesculetin (4 -me) and evaluation in the treatment of inflammatory intestinal disease. Thus, this process can be categorised as a pharmaceutical and /or pharmacologically active product because it is a process of obtaining polymer nano /microparticles preferably using chitosan as polymer, and before that it has direct application In the areas of pharmacy, medicine, biomedicine, chemistry and biotechnology. Yet,This invention describes the encapsulation of the active principle 4 -me in the nano /microparticles for preferential treatment of inflammatory bowel disease. For the development of said polymeric nano /microparticles by employing reticulated chitosan with sodium tripolyphosphate by the ionotropic gel method, as well as the nano /microparticles obtained, the following steps of 1 and 2 should be considered: (1) prep Aro of the solution of chitsana and sodium tripolyphosphate separately and (2) ionotropic gelification. At last,It is evident that the nano /microencapsulation of 4 -me with appropriate polymers aims at better targeting and releasing the asset into the target tissue, and consequently increases its bioavailability and therapeutic effect. In addition, the end product may be an active ingredient for new pharmaceutical formulations.a presente patente de invenção (pi) diz respeito a um processo de obtenção de nano e micropartículas encapsulando 4-metilesculetina (4-me) e avaliação no tratamento da doença inflamatória intestinal. assim, o dito processo pode ser categorizado como um produto farmacêutico e/ou farmacologicamente ativo tendo em vista que se trata de um processo de obtenção de nano/micropartículas poliméricas preferencialmente utilizando a quitosana como polímero, e, diante disso possui aplicação direta nas áreas de farmácia, medicina, biomedicina, química e biotecnologia. ainda, esta invenção descreve a encapsulação do princípio ati
