The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.本發明係關於經取代咪唑并嗒化合物、製備該等化合物之方法、包含該等化合物之醫藥組合物及組合及該等化合物用於製造作為單一藥劑或與其他活性成分組合供治療或預防疾病(特定言之過度增生性及/或血管生成病症)用之醫藥組合物的用途。