The present invention relates to substituted thienopyrimidine compounds of general formula (I)as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.本發明係關於如本文所描述及定義之通式(I)之經取代噻吩并嘧啶化合物製備該等化合物之方法、適用於製備該等化合物之中間化合物、包含該等化合物之醫藥組合物及組合，及該等化合物用於製造醫藥組合物的用途，其可作為單獨藥劑或與其他活性成分組合，用以治療或預防疾病，詳言之過度增生性及/或血管新生性病症。
