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MODULATION OF AQUAPORINS WITH RELAXIN
专利权人:
ИНК. (US);ЮНИВЕРСИТИ ОФ МЕЛЬБУРН (AU);ДЗЕ ЮНИВЕРСИТИ ОФ ФЛОРИДА РИСЕРЧ ФАУНДЕЙШН, ИНК. (US);ДЗЕ ЮНИВЕРСИТИ ОФ ФЛОРИДА РИСЕРЧ ФАУНДЕЙШН
发明人:
Лора ПАРРИ (AU),Керк КОНРАД (US)
申请号:
RU2012142985/15
公开号:
RU2012142985A
申请日:
2011.03.10
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of modulating the aquaporin channel in a mammal, which consists in administering relaxin in an amount effective to modify the expression of aquaporin in mammalian tissue. The method of claim 1, wherein the expression of aquaporin is the expression of the aquaporin gene. The method according to claim 2, in which the increasing expression of the aquaporin gene is carried out. The method of claim 2, wherein the down-regulation of the aquaporin gene is carried out. The method of claim 1, wherein the expression of aquaporin is the expression of the aquaporin protein. The method according to claim 5, in which the increasing expression of the aquaporin protein is carried out. The method according to claim 5, wherein the aquaporin protein is down-regulated. The method of claim 1, wherein the aquaporin channel is selected from the group consisting of aquaporin-0 (AQP0), aquaporin-1 (AQP1), aquaporin-2 (AQP2), aquaporin-3 (AQP3), aquaporin-4 (AQP4), aquaporin-5 (AQP5), aquaporin-6 (AQP6), aquaporin-7 (AQP7), aquaporin-8 (AQP8), aquaporin-9 (AQP9) and aquaporin-10 (AQP10) .9. The method of claim 8, wherein the aquaporin channel is selected from the group consisting of aquaporin-1 (AQP1), aquaporin-2 (AQP2), aquaporin-3 (AQP3), aquaporin-4 (AQP4) and aquaporin-5 (AQP5). ten. The method according to claim 9, wherein the up-regulation of AQP3 in the cervix is carried out. The method of claim 9, wherein the down regulation of AQP5 is performed in the cervix. The method of claim 9, wherein up-regulation of AQP2 in the kidney is carried out. The method of claim 9, wherein up-regulation of AQP4 in the kidney is carried out. The method of claim 1, wherein the tissue is selected from the group comprising organ tissue, muscle tissue, epithelial tissue, and endothelial tissue. The method of claim 14, wherein the organ tissue is selected from the group consisting of brain tissue, tissue p1. Способ модулирования аквапоринового канала у млекопитающего, заключающийся в том, что в
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