Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный технологический институт (технический университет)" (RU)
发明人:
Мелино Дженнаро (IT),Гарабаджиу Александр Васильевич (RU),Барлев Николай Анатольевич (RU),Трибулович Вячеслав Генрихович (RU),Розен Татьяна Алексеевна (RU)
申请号：
RU2012151377/15
公开号：
RU2012151377A
申请日:
2012.11.30
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of inhibiting the catalytic activity a protein complex CDL4a-DDB1, leading to an increase in the concentration of p73 protein and / or its isoforms, wherein the inhibition is effected by use DDB1.2-inhibitor agent. The method of claim 1, wherein the inhibition of the catalytic activity CDL4a-DDB1 protein complex is carried out by reducing the concentration and / or expression DDB1.3 protein. The method of claim 1, wherein the inhibition of the catalytic activity CDL4a-DDB1 protein complex is carried out by use of an agent which inhibits interaction with DDB1 CDL4a.4. The method of claim 1, wherein the inhibition of the catalytic activity CDL4a-DDB1 protein complex is carried out by use of an agent which inhibits interaction site DDB1 sr73.5. The method of claim 1, wherein the inhibition of the catalytic activity of the protein complex CDL4a-DDB1 used to treat diseases involving decrease p73 protein concentration and / or its izoform.6. A method according to claim 5, wherein the disease is cancer, an autoimmune or allergicheskim.7. A method for treating proliferative diseases involving decrease in the concentration of p73 protein and / or its isoforms according to claim 1, by inhibiting the catalytic activity a protein complex CDL4a-DDB1, comprising administering to a subject in need thereof an agent that inhibits the activity of the protein DDB1.8. A method according to claim 7, wherein the agent reduces DDB1 inhibitor protein activity by reducing its concentration and / or ekspressii.9. A method according to claim 7, wherein the protein complex CDL4a-DDB1 carries out post-translational modification of p73 protein and / or its isoforms by monoubikvitinilirovaniya.10. A method according to claim 7, wherein the inhibition of the catalytic activity CDL4a-DDB1 protein complex is carried out1. Способ ингибирования каталитической активности белкового комплекса CDL4a-DDB1, приводящий к увеличению концентрации белка р73 и/или его изоформ, где ингибирование осуще
