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КРИЗОТИНИБ ДЛЯ ПРИМЕНЕНИЯ В ЛЕЧЕНИИ РАКА
专利权人:
ПФАЙЗЕР ИНК. (US)
发明人:
КРИСТЕНСЕН Джеймс Гейл (US),ЗОУ Йахонг (US)
申请号:
RU2014102935/15
公开号:
RU2014102935A
申请日:
2012.07.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of treating cancer in a mammal which comprises administering to said mammal a therapeutically effective amount of or a pharmaceutically acceptable salt thereof, wherein the cancer is mediated by at least one genetically modified ROS.2. The method of claim 1 wherein the mammal is chelovek.3. The method of claim 1 wherein at least one genetically altered ROS is a genetically modified genome ROS.4. A method according to claim 3, wherein the genetically modified gene is a fusion gene ROS ROS.5. The method of claim 4, wherein the fusion gene is ROS SLC34A2-ROS gene or CD74-ROS.6. The method of claim 4, wherein the fusion gene is ROS FIG-ROS.7. The method of claim 1 wherein at least one genetically altered ROS is a fusion protein ROS.8. The method of claim 7, wherein the fusion protein is ROS kinazu.9 SLC34A2-ROS. The method of claim 7, wherein the fusion protein is ROS kinazu.10 CD74-ROS. The method of claim 7, wherein the fusion protein is ROS kinazu.11 FIG-ROS. A method according to any one of claims 1-10, wherein the cancer is selected from the following: lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head or neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer, cancer of the anal region, stomach cancer, colon cancer, breast cancer, carcinoma of the fallopian tubes, carcinoma of the endometrium, carcinoma of the cervix, carcinoma of the vagina, carcinoma of the vulva, Hodgkins disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, thyroid cancer, parathyroid gland, cancer of the adrenal gland, sarcoma of soft tissue, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, lymphocytic lymphoma, cancer of the urinary1. Способ лечения рака у млекопитающего, который включает введение указанному млекопитающему терапевтически эффективного количества 3-[(R)-1-(2,6-дихлор-3-фтор-фенил)-этокси]-5-(1-пиперидин-4-ил-1H-пиразол-4-ил)-пир
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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