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СПОСОБЫ РЕГУЛИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ СИРТУИНОВ
专利权人:
НЕСТЕК С.А. (CH)
发明人:
ПАНЬ Юйаньлун (US),МИДДЛТОН Рондо Пол (US)
申请号:
RU2013150828/10
公开号:
RU2013150828A
申请日:
2012.03.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for regulating gene expression sirtuin in an animal comprising administering one or more isoflavones to the animal a therapeutically effective kolichestve.2. A method according to claim 1, wherein the expressible gene Sirtuin represents at least one of SIRT1, SIRT2, SIRT3, SIRT4, SIRT5 or SIRT7.3. A method according to claim 1, wherein the expressible gene Sirtuin represents at least one of SIRT2 or SIRT3.4. A method according to claim 1, wherein the expressible gene Sirtuin represents at least one of SIRT4, SIRT5 or SIRT7.5. The method of claim 1 wherein the isoflavones are selected from the group consisting of isoflavones in the aglucone form, glucosides, and atsetilglyukozidov malonilglyukozidov.6. The method of claim 1 wherein the isoflavones are selected from the group consisting of biochanin A, daidzein, daidzin, glycitein, formononetin, equol, genistein, irilona, ​​lyuteona, prunetina, and pratenzeina glitsitina.7. The method of claim 1 wherein the isoflavones are administered in an amount from about 0.001 to about 10 g / kg / den.8. The method of claim 1 wherein the isoflavones are administered to the animal as a dietary supplement or food kompozitsii.9. A method according to claim 8, wherein the isoflavones are administered in a food composition and the content of isoflavones is from about 0.001 to about 40% of the food kompozitsii.10. A method according to claim 1, wherein the animal is a human or pet zhivotnoe.11. The process simulation of caloric restriction in an animal comprising administering one or more isoflavones to the animal a therapeutically effective amount to regulate gene expression and thereby sirtuins simulation kaloriynosti.12 limitations. A method according to claim 11, wherein the expressible gene Sirtuin represents at least one of SIRT1, S1. Способ регулирования экспрессии генов сиртуинов у животного, включающий введение одного или более изофлавонов животному в терапевтически эффективном количестве.2. Способ по п.1, в которо
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